Corinthian Reference Lab (CRL) is a commercial diagnostic laboratory specializing in testing for and detection of neurological diseases like small fiber neuropathy, fibromyalgia, or dysautonomia. Based in Fort Worth, Texas, we specialize exclusively in epidermal nerve fiber density (ENFD) testing, or ENFD testing. This type of small fiber neuropathy testing offers medical providers with objective evidence of a small fiber neuropathy which can hopefully lead to a more accurate diagnosis. Through advanced technology and accurate diagnostic analysis by experienced dedicated personnel, CRL plays an important role in early detection and disease monitoring.

Physicians choose CRL for our expertise in performing this very specific labor intensive test. Specimens require extensive manual manipulation and nerve fibers are counted manually. Each case is read by both a neuromuscular neurologist and a dermatopathologist to provide the most specialized interpretations of the patient’s specimen. At Corinthian Reference Lab, we are committed to providing the most accurate diagnostic small fiber neuropathy testing available so that each patient ultimately receives the best possible care.

What is small fiber neuropathy?

Small fiber peripheral neuropathy is a type of peripheral neuropathy that occurs from damage to the small unmyelinated peripheral nerve fibers, which are found in skin, peripheral nerves, and organs. Although there are many possible causes of small fiber neuropathy, the most common is diabetes or glucose intolerance. These fibers supply the skin with nerves and help control autonomic functions. Although symptoms of small fiber neuropathy vary widely, it’s usually first accompanied by pain, numbness, discomfort in the hands and feet, or an insensitivity to pain. Because small fiber neuropathy can relate to a range of health conditions, please see our FAQ pages for more information on how CRL’s small fiber neuropathy testing can help diagnose a patient’s specific condition. 


The Clinical Professionals:

Mary E. Landau, M.D. is triple board certified in Anatomic Pathology, Clinical Pathology, and Dermatopathology. She serves as the medical director of Corinthian Reference Laboratory. Dr. Landau graduated from Duke University Medical School and completed her Anatomic and Clinical Pathology Residency as well as her fellowship in Dermatopathology at Washington University in St. Louis. Her areas of small fiber neuropathy expertise include inflammatory and painful skin disorders, melanocytic lesions of the skin and medical illustration.

David Saperstein, M.D. is a graduate of Boston University School of Medicine. He completed his Neurology residency at Wilford Hall USAF Medical Center in San Antonio, Texas, followed by a Neuromuscular Disease/Clinical Neurophysiology fellowship at the University of Texas Southwestern Medical Center in Dallas. Dr. Saperstein is board certified in Neurology, Neuromuscular Medicine and Electrodiagnostic Medicine. Dr. Saperstein participated in multicenter research studies of treatments for amyotrophic lateral sclerosis, myasthenia gravis, immune-mediated neuropathies, and muscular dystrophy. Dr. Saperstein has authored or co-authored over 40 journal articles, book chapters and abstracts regarding various aspects of nerve and muscle diseases like small fiber neuropathy. He is a Neuromuscular Neurologist for CRL.

Todd Levine, M.D. is a graduate of Duke University Medical School. He completed his internship in Internal Medicine at Jewish Hospital in St Louis. He completed his neurology residency at Barnes Hospital in St Louis. He then completed a two year fellowship in neuromuscular disease at Washington University in St Louis and is board certified in Neurology as well as Electrodiagnostic Medicine. He is Co-Director of the neurophysiology department at Banner Good Samaritan Medical Center. He also conducts extensive research in diseases of the nerve and muscle (like small fiber neuropathy) and continues to publish his findings in numerous peer reviewed journals. Dr. Levine also serves as a Neuromuscular Neurologist for CRL.